Keck Lab

Our research group is working to understand the mechanisms of neuroplasticity and their consequences for behavior. Specifically, we are interested in both homeostatic and Hebbian plasticity and how these forms of plasticity interact to facilitate circuit reorganization that follows sensory deprivation or input loss and the implications for subsequent behavior. We use a combination of experimental approaches including in vivo imaging, electrophysiology and viral tools to investigate the structural and functional changes to neurons in the brain that follow from changes to the peripheral nervous system, and the consequences of these changes for behavior. We complement these laboratory studies with population studies to identify critical aspects for healthy brain plasticity during aging. Our long-term goals are to understand how these mechanisms work in the healthy brain and how they might be used improve functional recovery and rehabilitation following input loss associated with insults like stroke, hearing loss or retinal degeneration.